NEPHRON-SPARING APPROACH TO BILATERAL WILMS-TUMOR - INSITU OR EXVIVO SURGERY AND RADIATION-THERAPY JOURNAL OF PEDIATRIC SURGERY Longaker, M. T., Harrison, M. R., Adzick, N. S., Crombleholme, T. M., Langer, J. C., Duncan, B. W., Halberg, F. E., Salvatierra, O. 1990; 25 (4): 411-414


Bilateral Wilms' tumor patients, who experience local recurrence after maximal multimodality therapy, present a difficult surgical problem. The role of surgery in the management of these patients has changed from ablation to preservation of renal tissue, with bilateral nephrectomy as a last resort. Two children who had recurrent tumors in the remaining kidney underwent nephron-sparing surgery and focal intraoperative radiation therapy. In one case, this nephron-sparing surgery and intraoperative radiation therapy were performed in situ, in the other kidney was removed and reimplanted (ex vivo bench surgery and irradiation). These techniques may allow complete obliteration of gross and microscopic disease, while maximizing residual renal function.

View details for Web of Science ID A1990CX79100009

View details for PubMedID 2158540