Abstract

Positron emission tomography (PET) is a diagnostic tool for lung cancer evaluation. No studies have ascertained practice patterns and determined the appropriateness of PET use in a large group of U.S. patients with screen detected lung nodules.We analyzed participants in the National Lung Screening Trial (NLST) with positive screening test results and identified individuals with a PET scan performed prior to lung cancer diagnosis (diagnostic PET). Appropriate scan was defined as one performed in a patient with a nodule = 0.8 cm. Logistic regression was used to assess factors associated with diagnostic PET use and appropriateness of PET use.Diagnostic PET was performed in 1,556 of 14,195 (11%) patients with positive screens; 331 of these (21%) were inappropriate. PET use by endemic fungal disease area was comparable although patients from the Northeast/Southeast were twice as likely as the West to have a diagnostic PET. Trial arm, older age, gender, nodule size = 0.8 cm, upper lobe location, and spiculated margin were variables positively associated with use. Trial arm, older age and spiculated margin were positively associated with appropriate use. Only 561 (36%) diagnostic PETs were recommended by a radiologist and 284 (86%) PETs performed for nodules < 0.8 cm were ordered despite no recommendation from a radiologist.PET was differentially utilized in the NLST and inappropriately used in many cases against radiologist recommendations. These data suggest PET may be over utilized in the lung cancer screening population and may contribute to excess healthcare costs.

View details for DOI 10.1016/j.chest.2016.05.006

View details for PubMedID 27179906