Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus medical therapy for acute coronary syndromes - Exploration of methods CIRCULATION Pieper, K. S., Tsiatis, A. A., Davidian, M., Hasselblad, V., Kleiman, N. S., Boersma, E., Chang, W. C., Griffin, J., Armstrong, P. W., Califf, R. M., Harrington, R. A. 2004; 109 (5): 641-646


Although many believe that platelet glycoprotein IIb/IIIa inhibitors should be used only in acute coronary syndrome patients undergoing percutaneous coronary intervention, supporting data from randomized clinical trials are tenuous. The assumption that these agents are useful only in conjunction with percutaneous coronary intervention is based primarily on inappropriate subgroup analyses performed across the glycoprotein IIb/IIIa inhibitor trials.We describe the problems with these analytical techniques and demonstrate that different approaches to the question can result in opposing answers.Clinical-practice decisions and practice guidelines should be based on overall trial results and not analyses of post-randomization subgroups.

View details for DOI 10.1161/01.CIR.0000112570.97220.89

View details for Web of Science ID 000188836600016

View details for PubMedID 14769687