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LONG-TERM SURVIVAL OF SKIN ALLOGRAFTS IN MICE TREATED WITH FRACTIONATED TOTAL LYMPHOID IRRADIATION SCIENCE Slavin, S., Strober, S., Fuks, Z., KAPLAN, H. S. 1976; 193 (4259): 1252-1254

Abstract

Treatment of recipient Balb/c mice with fractionated, high-dose total lymphoid irradiation, a procedure commonly used in the therapy of human malignant lymphomas, resulted in fivefold prolongation of the survival of C57BL/Ka skin allografts despite major histocompatibility differences between the strains (H-2d and H-2b, respectively). Infusion of 10(7) (C57BL/Ka x Balb/c)F1 bone marrow cells after total lymphoid irradiation further prolonged C57BL/Ka skin graft survival to more than 120 days. Total lymphoid irradiation may eventually prove useful in clinical organ transplantation.

View details for Web of Science ID A1976CD84600022

View details for PubMedID 785599