CHARACTERIZATION OF A SPONTANEOUS MURINE B-CELL LEUKEMIA (BCL1) .1. CELL-SURFACE EXPRESSION OF IGM, IGD, IA, AND FCR JOURNAL OF IMMUNOLOGY Knapp, M. R., Jones, P. P., Black, S. J., Vitetta, E. S., Slavin, S., Strober, S. 1979; 123 (3): 992-999

Abstract

The surface marker expression of a spontaneous B lymphocyte leukemia discovered in a BALB/c mouse (BCL1) was examined and found to include a subset of markers known to occur on normal B lymphocytes. The tumor cells bore surface Ig that included both mu- and delta-chains associated with the lambda light chain. Alloantigens coded for within the murine MHC, including H-2D, H-2K, and I-region products, were identified on the tumor cells. Although normal B lymphocytes are thought to express products coded for within both the I-A and I-E subregions, the BCL1 expressed only normal amounts of I-E subregion products. In addition, the H-2 and Ia antigens revealed by 2-dimensional gel electrophoresis exhibited an abnormal pattern of post-translational modifications. The Fc, but not the complement-receptor, was present on the surface of tumor cells. The presence of IgD, Ia antigens, and the responsiveness to lipopolysaccharide (see subsequent paper) have led us to postulate that the BCL1 tumor represents a later differentiative stage than murine B lymphocyte tumors previously described.

View details for Web of Science ID A1979HH67000005

View details for PubMedID 313960