Skip to main content
REGULATION OF EXTRACELLULAR POTASSIUM CONCENTRATION IN EPILEPTOGENESIS FEDERATION PROCEEDINGS Pedley, T. A., Fisher, R. S., FUTAMACHI, K. J., Prince, D. A. 1976; 35 (6): 1254-1259

Abstract

Characteristic elevations in the brain's extracellular potassium concentration [K+]0 occur during focal epileptogenesis. These changes have particular spatial and temporal profiles that are different in hippocampus and neocortex, and in mature and immature animals. Increases in [K+]0 cannot be the sole explanation for regional variations in seizure susceptibility, interictal-ictal transitions, or termination of ictal episodes. Excess [K+]0 is cleared primarily by passive diffusion with a small amount taken up into cells and blood vessels. Cortical neuroglia have sensitivities to changes in [K+]0 similar to that observed in glial cells in invertebrates and amphibia. However, discrepancies in the expected relationship between [K+]o and glial membrane potential Vm suggest either a heterogeneous population of glial cell types and/or the presence of a glial syncytium which acts as a spatial buffer to increases in [K+]0.

View details for Web of Science ID A1976BR08700005

View details for PubMedID 816678