Diagnostic value of time-resolved CT angiography for the lower leg EUROPEAN RADIOLOGY Sommer, W. H., Helck, A., Bamberg, F., Albrecht, E., Becker, C. R., Weidenhagen, R., Kramer, H., Reiser, M. F., Nikolaou, K. 2010; 20 (12): 2876-2881


The aim of this study was to test the feasibility of time-resolved computed tomography angiography (TR-CTA) for use in the lower leg.Fifty-nine patients with suspected peripheral arterial occlusive disease were examined with a standard CTA (S-CTA) of the lower run-off and with an additional TR-CTA of the calves (12 phases; 2.5 s/phase, 80 kV, 120 mAs, volume of contrast medium 50 mL, flow rate 5.0 mL/s). For seven lower-leg artery segments, arterial contrast and the presence of venous overlay were tested for S-CTA and TR-CTA. Stenoses were classified on a three-point scale separately for S-CTA and TR-CTA, and diagnostic confidence for stenosis assessment was evaluated for both datasets. Contrast arrival times and HU values were evaluated in patients with asymmetric proximal stenoses.TR-CTA resulted in significantly higher contrast enhancement (P < 0.0001) and less venous overlay as compared to S-CTA (P < 0.05). Diagnostic confidence for stenosis rating was significantly higher in TR-CTA (P < 0.0001). Asymmetric proximal stenoses lead to significantly delayed and diminished contrast enhancement on the stenotic side.TR-CTA of the calves is feasible and provides higher enhancement and higher diagnostic confidence as compared to monophasic CTA of the lower legs.

View details for DOI 10.1007/s00330-010-1861-0

View details for Web of Science ID 000284117000013

View details for PubMedID 20589380