F-18-fluoro-2-deoxyglucose positron emission tomography/computed tomography in the follow-up of breast cancer with elevated levels of tumor markers JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY Haug, A. R., Schmidt, G. P., Klingenstein, A., Heinemann, V., Stieber, P., Priebe, M., La Fougere, C., Becker, C., Hahn, K., Tiling, R. 2007; 31 (4): 629-634


The value of combined positron emission tomography (PET)/computed tomography (CT) in the follow-up of patients with breast cancer with elevated tumor markers but without proven metastases or local recurrence was assessed.Thirty-four women underwent PET/CT. The PET and CT images were first analyzed separately; fused findings were then interpreted, blinded to the results of the other modalities. The results of CT, PET, and PET/CT were compared with each other and correlated to the final diagnosis.The PET/CT identified 149 malignant foci in 24 patients (71%). The CT detected 96 of these foci in 18 patients, whereas PET identified 124 foci in 17 patients. Differences between CT and PET were not significant. Differences between PET/CT and CT (P < 0.01) and PET/CT and PET (P < 0.01) were significant. The person-based sensitivity of PET/CT, PET, and CT was 96%, 88% and 96%, respectively. Specificity of PET/CT, PET, and CT was 89%, 78%, and 78%, respectively.The PET/CT is a valuable modality for the follow-up of patients with breast cancer and elevated levels of tumor markers.

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View details for PubMedID 17882045