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Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibroses? JOURNAL OF CLINICAL INVESTIGATION Douglas, I. S., Nicolls, T. R. 2005; 115 (5): 1133-1136

Abstract

Angiogenesis may be an important factor in the development of fibrotic lung disease. Prior studies have strongly suggested a role for angiogenic vascular remodeling in pulmonary fibrosis, and emerging evidence indicates that new vessel formation is critical in airway fibrosis. Bronchiolitis obliterans syndrome is a fibrotic occlusion of distal airways that is largely responsible for the morbidity and mortality of patients after lung transplantation. In this issue, Belperio et al. demonstrate a role for CXC chemokine receptor 2 in the regulation of angiogenesis-mediated airway fibroproliferation. By integrating an understanding of neovascularization into the study of events that occur between inflammation and fibrosis, it becomes increasingly possible to rationally design therapies that can halt conditions of maladaptive fibrosis.

View details for DOI 10.1172/JCI200525193

View details for Web of Science ID 000228908300010

View details for PubMedID 15864341

View details for PubMedCentralID PMC1087192