Infection-resistant MRI-visible scaffolds for tissue engineering applications. BioImpacts : BI Mahmoudi, M., Zhao, M., Matsuura, Y., Laurent, S., Yang, P. C., Bernstein, D., Ruiz-Lozano, P., Serpooshan, V. 2016; 6 (2): 111-115


Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.

View details for DOI 10.15171/bi.2016.16

View details for PubMedID 27525229