Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system SCIENCE TRANSLATIONAL MEDICINE Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., Delp, S. L. 2016; 8 (337)

Abstract

Optogenetics offers promise for dissecting the complex neural circuits of the spinal cord and peripheral nervous system and has therapeutic potential for addressing unmet clinical needs. Much progress has been made to enable optogenetic control in normal and disease states, both in proof-of-concept and mechanistic studies in rodent models. In this Review, we discuss challenges in using optogenetics to study the mammalian spinal cord and peripheral nervous system, synthesize common features that unite the work done thus far, and describe a route forward for the successful application of optogenetics to translational research beyond the brain.

View details for DOI 10.1126/scitranslmed.aad7577

View details for Web of Science ID 000375802500004

View details for PubMedID 27147590