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Up-regulation of fibroblast growth factor-binding protein, by beta-catenin during colon carcinogenesis CANCER RESEARCH Ray, R., Cabal-Manzano, R., Moser, A. R., Waldman, T., Zipper, L. M., Aigner, A., BYERS, S. W., Riegel, A. T., Wellstein, A. 2003; 63 (23): 8085-8089

Abstract

Fibroblast growth factor-binding protein (FGF-BP) releases immobilized FGFs from the extracellular matrix and can function as an angiogenic switch molecule in cancer. Here we show that FGF-BP is up-regulated in early dysplastic lesions of the human colon that are typically associated with a loss of adenomatous polyposis coli and up-regulation of beta-catenin. In addition, FGF-BP expression is induced in dysplastic lesions in ApcMin/+ mice in parallel with the up-regulation of beta-catenin. Also, in cell culture studies FGF-BP is induced by beta-catenin through direct activation of the FGF-BP gene promoter. We conclude that FGF-BP is a target gene of beta-catenin.

View details for Web of Science ID 000187450900003

View details for PubMedID 14678957