MICRORIPS OF THE RETINAL-PIGMENT EPITHELIUM ARCHIVES OF OPHTHALMOLOGY Ie, D., Yannuzzi, L. A., Spaide, R. F., WOODWARD, K. P., Singerman, L. J., Blumenkranz, M. S. 1992; 110 (10): 1443-1449


We describe six patients with exudative age-related macular degeneration who had retinal pigment epithelial detachments with associated overlying neurosensory detachments. During fluorescein angiography, each patient demonstrated a solitary, intense, central serouslike leak at the edge of the retinal pigment epithelial detachment with passage of fluorescein into the subretinal space. In patients in whom the location of associated choroidal neovascularization was evident, the leakage site was remote to the area of neovascularization. Our observations suggest that these leaks result from small retinal epithelial rips, which we termed "microrips," that differ from conventionally described retinal pigment epithelial rips in clinical course and response to laser treatment. We hypothesize that the mechanisms and forces that generate these microrips are different from those producing conventionally described retinal pigment epithelial rips.

View details for Web of Science ID A1992JT34900024

View details for PubMedID 1384462