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CBP/p300 acetyltransferase activity in hematologic malignancies. Molecular genetics and metabolism Dutta, R., Tiu, B., Sakamoto, K. M. 2016; 119 (1-2): 37-43

Abstract

CREB binding protein (CBP) and p300 are critical regulators of hematopoiesis through both their transcriptional coactivator and acetyltransferase activities. Loss or mutation of CBP/p300 results in hematologic deficiencies in proliferation and differentiation as well as disruption of hematopoietic stem cell renewal and the microenvironment. Aberrant lysine acetylation mediated by CBP/p300 has recently been implicated in the genesis of multiple hematologic cancers. Understanding the effects of disrupting the acetyltransferase activity of CBP/p300 could pave the way for new therapeutic approaches to treat patients with these diseases.

View details for DOI 10.1016/j.ymgme.2016.06.013

View details for PubMedID 27380996