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Genome-wide linkage analysis and regional fine mapping identified variants in the RYR3 gene as a novel quantitative trait locus for circulating adiponectin in Chinese population MEDICINE Chang, Y., Chiu, Y., He, C., Sheu, W. H., Lin, M., Seto, T. B., Assimes, T., Jou, Y., Su, L., Lee, W., Lee, P., Tsai, S., Chuang, L. 2016; 95 (44)

Abstract

Adiponectin is adipocyte-secreted cytokine with potent insulin-sensitizing action in peripheral tissues. The heritability of plasma adiponectin is high in Han Chinese population.To identify genetic loci influencing plasma adiponectin levels in Chinese population, we performed a genome-wide linkage scan in 1949 Chinese participants of the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance family study and mapped a quantitative trail locus located on chromosome 15 at 31?cM (logarithm of odds?=?3.04) with 1-logarithm of odds support interval at 24 to 34?cM. Within this mapped region, we further genotyped a total of 68 single-nucleotide polymorphisms in 12 genes. Association analysis revealed that haplotypes composed of single-nucleotide polymorphisms in the ryanodine receptor 3 (RYR3) gene had strongest association with plasma adiponectin. RYR3 haplotypes were also associated with systolic (P?=?0.001) and diastolic (P?=?7.1?×?10) blood pressure and high-density lipoprotein cholesterol (P?=?1.4?×?10). Furthermore, an inverse relationship between expression of RYR3 and adiponectin was observed in human abdominal adipose tissue. In conclusion, a genome-wide linkage scan and regional association fine-mapping identified variants in the RYR3 gene as a quantitative trail locus for plasma adiponectin levels in Chinese population.

View details for DOI 10.1097/MD.0000000000005174

View details for Web of Science ID 000388566200018

View details for PubMedID 27858853