Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease MOVEMENT DISORDERS Bronstein, J. M., Paul, K., Yang, L., Haas, R. H., Shults, C. W., Le, T., Ritz, B. 2015; 30 (6): 862-866


Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.

View details for DOI 10.1002/mds.26164

View details for Web of Science ID 000354731500021

View details for PubMedID 25757798

View details for PubMedCentralID PMC4439327