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Abstract
Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n?=?8863) and trans-ethnic replication in African Americans (n?=?4111). We found differential methylation at 218 CpG sites to be associated with CRP (P?
View details for DOI 10.1186/s13059-016-1119-5
View details for Web of Science ID 000390199000001
View details for PubMedID 27955697