Stem Cells in Bone Regeneration STEM CELL REVIEWS AND REPORTS Walmsley, G. G., Ransom, R. C., Zielins, E. R., Leavitt, T., Flacco, J. S., Hu, M. S., Lee, A. S., Longaker, M. T., Wan, D. C. 2016; 12 (5): 524-529


Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.

View details for DOI 10.1007/s12015-016-9665-5

View details for Web of Science ID 000385138500003

View details for PubMedID 27250635

View details for PubMedCentralID PMC5053855