Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation. Advanced healthcare materials Cai, L., Dewi, R. E., Goldstone, A. B., Cohen, J. E., Steele, A. N., Woo, Y. J., Heilshorn, S. C. 2016


A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

View details for DOI 10.1002/adhm.201600497

View details for PubMedID 27709809