New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations.
Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia Koch, T. A., Myers, J., Goodnough, L. T. 2015; 2015: 763576-?Abstract
Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies. For the second of the larger studies (Study 7), we also compared the efficacy and retreatment requirements of a cumulative dose of 1500?mg ferric carboxymaltose (FCM) to 1000?mg iron sucrose (IS). Results. The average iron deficit was calculated to be 1531?mg for patients in Studies 1-5 and 1392?mg for patients in Studies 6-7. The percentage of patients who were retreated with IV iron between Days 56 and 90 was significantly (p < 0.001) lower (5.6%) in the 1500?mg group, compared to the 1000?mg group (11.1%). Conclusions. Our data suggests that a total cumulative dose of 1000?mg of IV iron may be insufficient for iron repletion in a majority of patients with IDA and a dose of 1500?mg is closer to the actual iron deficit in these patients.
View details for DOI 10.1155/2015/763576
View details for PubMedID 26257955
View details for PubMedCentralID PMC4518169