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Current Approaches and Recent Developments in the Management of Head and Neck Paragangliomas ENDOCRINE REVIEWS Taieb, D., Kaliski, A., Boedeker, C. C., Martucci, V., Fojo, T., Adler, J. R., Pacak, K. 2014; 35 (5): 795-819

Abstract

Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors belonging to the family of pheochromocytoma/paraganglioma neoplasms. Despite advances in understanding the pathogenesis of these tumors, the growth potential and clinical outcome of individual cases remains largely unpredictable. Over several decades, surgical resection has long been the treatment of choice for HNPGLs. However, increasing experience in various forms of radiosurgery has been reported to result in curative-like outcomes, even for tumors localized in the most inaccessible anatomical areas. The emergence of such new therapies challenges the traditional paradigm for the management of HNPGLs. This review will assist and guide physicians who encounter patients with such tumors, either from a diagnostic or therapeutic standpoint. This review will also particularly emphasize current and emerging knowledge in genetics, imaging, and therapeutic options as well as the health-related quality of life for patients with HNPGLs.

View details for DOI 10.1210/er.2014-1026

View details for Web of Science ID 000342346200004

View details for PubMedID 25033281

View details for PubMedCentralID PMC4167435