Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008 MAYO CLINIC PROCEEDINGS Yang, J. D., Kim, B., Sanderson, S. O., St Sauver, J. L., Yawn, B. P., Pedersen, R. A., Larson, J. J., Therneau, T. M., Roberts, L. R., Kim, W. R. 2012; 87 (1): 9-16


To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival.Olmsted County residents 20 years or older with HCC newly diagnosed from January 1, 1976, through December 31, 2008, were identified using a community-wide medical record linkage system (Rochester Epidemiology Project). The incidence rate of HCC was calculated by age and sex according to the 2000 US Census population. Temporal trends of HCC etiology, treatment, and patient survival were assessed.The age- and sex-adjusted incidence rate for HCC in Olmsted County was 3.5 per 100,000 person-years for the first era (1976-1990), 3.8 per 100,000 for the second era (1991-2000), and 6.9 per 100,000 for the third era (2001-2008). Alcohol use was the most common risk factor in the first and second eras and chronic hepatitis C virus in the third. The proportion attributed to nonalcoholic fatty liver disease was small (5/47 [10.6%] in the third era). Because the proportion of patients receiving curative treatment increased over time, survival also improved, with a median survival time of 3, 6, and 9 months in the first, second, and third eras, respectively (P=.01).In this midwestern US community, the incidence of HCC has increased, primarily due to hepatitis C virus. Although there was a demonstrable improvement in the outcome of HCC in community residents over time, the overall prognosis remains poor.

View details for DOI 10.1016/j.mayocp.2011.07.001

View details for Web of Science ID 000299667300003

View details for PubMedID 22212963

View details for PubMedCentralID PMC3538386