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Kruppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration MOLECULAR AND CELLULAR NEUROSCIENCE Moore, D. L., Apara, A., Goldberg, J. L. 2011; 47 (4): 233-243

Abstract

The Krüppel-like family of transcription factors (KLFs) have been widely studied in proliferating cells, though very little is known about their role in post-mitotic cells, such as neurons. We have recently found that the KLFs play a role in regulating intrinsic axon growth ability in retinal ganglion cells (RGCs), a type of central nervous system (CNS) neuron. Previous KLF studies in other cell types suggest that there may be cell-type specific KLF expression patterns, and that their relative expression allows them to compete for binding sites, or to act redundantly to compensate for another's function. With at least 15 of 17 KLF family members expressed in neurons, it will be important for us to determine how this complex family functions to regulate the intricate gene programs of axon growth and regeneration. By further characterizing the mechanisms of the KLF family in the nervous system, we may better understand how they regulate neurite growth and axon regeneration.

View details for DOI 10.1016/j.mcn.2011.05.005

View details for Web of Science ID 000293309500001

View details for PubMedID 21635952

View details for PubMedCentralID PMC3143062