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Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area SLEEP Gavrilov, Y. V., Ellison, B. A., Yamamoto, M., Reddy, H., Haybaeck, J., Mignot, E., Baumann, C. R., Scammell, T. E., Valko, P. O. 2016; 39 (5): 1059-1062

Abstract

To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients.Postmortem examination of five narcolepsy and eight control brains.VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544).A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

View details for DOI 10.5665/sleep.5754

View details for Web of Science ID 000375188400013

View details for PubMedID 26951397

View details for PubMedCentralID PMC4835304