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Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation CELL Gruber, J. J., Zatechka, D. S., Sabin, L. R., Yong, J., Lum, J. J., Kong, M., Zong, W., Zhang, Z., Lau, C., Rawlings, J., Cherry, S., Ihle, J. N., Dreyfuss, G., Thompson, C. B. 2009; 138 (2): 328-339

Abstract

Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.

View details for DOI 10.1016/j.cell.2009.04.046

View details for Web of Science ID 000268277000014

View details for PubMedID 19632182

View details for PubMedCentralID PMC2717034