Role of innate and adaptive immunity in obesity-associated metabolic disease JOURNAL OF CLINICAL INVESTIGATION McLaughlin, T., Ackerman, S. E., Shen, L., Engleman, E. 2017; 127 (1): 5-13

Abstract

Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR). Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process. Thus, M1 macrophages, IFN-?-secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part through secretion of proinflammatory cytokines. Conversely, eosinophils, Th2 T cells, type 2 innate lymphoid cells, and possibly Foxp3+ Tregs protect against IR through local control of inflammation.

View details for DOI 10.1172/JCI88876

View details for Web of Science ID 000392271300002

View details for PubMedID 28045397

View details for PubMedCentralID PMC5199693