Indications for antiviral therapy for chronic hepatitis B in pregnant mothers. BMJ case reports Yoo, E. R., Perumpail, R. B., Cholankeril, G., Ahmed, A. 2016; 2016


The use of antiviral therapy for chronic hepatitis B virus (HBV) infection in the setting of pregnancy needs to be individualised based on limited data. We report a case of a 34-year-old Korean-American woman with a history of pregnancy with emergent caesarean section due to prolonged labour in the setting of HBV e-antigen (HBeAg) positive chronic HBV with a pretreatment baseline HBV DNA level of 110000 000 million copies per mL. Her first delivery was complicated by mother-to-child transmission (MTCT) of HBV infection to her daughter despite standard active and passive immunoprophylaxis. Our case report highlights an important clinical decision-making step regarding the timing of antiviral therapy in the management of chronic HBV in pregnant women with high risk of MTCT.

View details for DOI 10.1136/bcr-2016-217232

View details for PubMedID 27852658