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Adaptive Immunity Dysregulation in Acute Coronary Syndromes From Cellular and Molecular Basis to Clinical Implications JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Flego, D., Liuzzo, G., Weyand, C. M., Crea, F. 2016; 68 (19): 2107-2117

Abstract

Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. This review discusses recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogenic concepts.

View details for DOI 10.1016/j.jacc.2016.08.036

View details for Web of Science ID 000386829300012

View details for PubMedID 27810051