Pediatric Anti-ganglionic Antibody Positive Autonomic Neuropathy: Clinical Presentation and Response to Treatment PEDIATRIC NEUROLOGY Tiongson, E., Pimentel, N., Ramos-Platt, L., Jaradeh, S. 2016; 64: 72-76


Autoimmune autonomic neuropathy is rare in children. There are few pediatric reports documenting anti-ganglionic antibodies.We present two children with anti-ganglionic antibody positive autonomic neuropathy, including their presentation, results of testing, and treatment course.Both children had delayed diagnoses because of the presence of vague autonomic symptoms. Treatment with multiple immunotherapies appears to bring at least a partial response and can be monitored with anti-ganglionic antibody titers.Our findings contribute to the sparse literature in pediatric autoimmune autonomic neuropathy and highlight the need for additional studies to create diagnostic criteria and define optimal treatment regimens.

View details for DOI 10.1016/j.pediatrneurol.2016.06.007

View details for Web of Science ID 000389169300013

View details for PubMedID 27569256