Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations HUMAN MOLECULAR GENETICS Seow, W. J., Matsuo, K., Hsiung, C. A., Shiraishi, K., Song, M., Kim, H. N., Wong, M. P., Hong, Y., Hosgood, H. D., Wang, Z., Chang, I., Wang, J., Chatterjee, N., Tucker, M., Wei, H., Mitsudomi, T., Zheng, W., Kim, J. H., Zhou, B., Caporaso, N. E., Albanes, D., Shin, M., Chung, L. P., An, S., Wang, P., Zheng, H., Yatabe, Y., Zhang, X., Kim, Y. T., Shu, X., Kim, Y., Bassig, B. A., Chang, J., Ho, J. C., Ji, B., Kubo, M., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S., Nokihara, H., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Yin, Z., Shi, J., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wu, T., Wei, F., Wong, J. Y., Matsuda, F., Su, J., Kim, Y. H., Oh, I., Song, F., Lee, V. H., Su, W., Chen, Y., Chang, G., Chen, K., Huang, M., Yang, P., Lin, H., Xiang, Y., Seow, A., Park, J. Y., Kweon, S., Chen, C., Li, H., Gao, Y., Wu, C., Qian, B., Lu, D., Liu, J., Jeon, H., Hsiao, C., Sung, J. S., Tsai, Y., Jung, Y. J., Guo, H., Hu, Z., Wang, W., Chung, C. C., Lawrence, C., Burdett, L., Yeager, M., Jacobs, K. B., Hutchinson, A., Berndt, S. I., He, X., Wu, W., Wang, J., Li, Y., Choi, J. E., Park, K. H., Sung, S. W., Liu, L., Kang, C. H., Hu, L., Chen, C., Yang, T., Xu, J., Guan, P., Tan, W., Wang, C., Sihoe, A. D., Chen, Y., Choi, Y. Y., Hung, J., Kim, J. S., Yoon, H., Cai, Q., Lin, C., Park, I. K., Xu, P., Dong, J., Kim, C., He, Q., Perng, R., Chen, C., Vermeulen, R., Wu, J., Lim, W., Chen, K., Chan, J. K., Chu, M., Li, Y., Li, J., Chen, H., Yu, C., Jin, L., Lo, Y., Chen, Y., Fraumeni, J. F., Liu, J., Yamaji, T., Yang, Y., Hicks, B., Wyatt, K., Li, S. A., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Li, X., Ren, Y., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Jiang, G., Fei, K., Wu, G., Chien, L., Chen, H., Su, Y., Tsai, F., Chen, Y., Yu, J., Stevens, V. L., Laird-Offringa, I. A., Marconett, C. N., Lin, D., Chen, K., Wu, Y., Landi, M. T., Shen, H., Rothman, N., Kohno, T., Chanock, S. J., Lan, Q. 2017; 26 (2): 454-465
Abstract
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P?
View details for DOI 10.1093/hmg/ddw414
View details for Web of Science ID 000397066400018
View details for PubMedCentralID PMC5856088
