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Abstract
We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program.We performed association analyses of cerebral and hippocampal volumes and white matter hyperintensity (WMH) in up to 2,180 individuals by testing the association of rank-normalized residuals from mixed-effect linear regression models adjusted for sex, age, and total intracranial volume with individual variants while accounting for familial relatedness. We conducted gene-based tests for rare variants using (1) a sliding-window approach, (2) a selection of functional exonic variants, or (3) all variants.We detected new loci in 1p21 for cerebral volume (minor allele frequency [MAF] 0.005,p= 10-8) and in 16q23 for hippocampal volume (MAF 0.05,p= 2.7 × 10-8). Previously identified associations in 12q24 for hippocampal volume (rs7294919,p= 4.4 × 10-4) and in 17q25 for WMH (rs7214628,p= 2.0 × 10-3) were confirmed. Gene-based tests detected associations (p= 2.3 × 10-6) in new loci for cerebral (5q13, 8p12, 9q31, 13q12-q13, 15q24, 17q12, 19q13) and hippocampal volumes (2p12) and WMH (3q13, 4p15) including Alzheimer disease- (UNC5D) and Parkinson disease-associated genes (GBA). Pathway analyses evidenced enrichment of associated genes in immunity, inflammation, and Alzheimer disease and Parkinson disease pathways.Whole genome sequence-wide search reveals intriguing new loci associated with brain measures. Replication of novel loci is needed to confirm these findings.
View details for DOI 10.1212/WNL.0000000000004820
View details for PubMedID 29282330
View details for PubMedCentralID PMC5772158