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Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy ONCOIMMUNOLOGY Filatenkov, A., Baker, J., Strober, S. 2016; 5 (2): e1072673
Abstract
Radiation administered to murine colon tumors induced durable remissions that were dependent on CD4+ and CD8+ T cell immunity, and antigen cross priming CD8+ dendritic cells (DCs). Remissions were associated with marked reductions in the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and Treg cells, and a marked increase in CD8+ T cells.
View details for PubMedID 27057471