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COMPARISON OF PSYLLIUM HYDROPHILIC MUCILLOID AND CELLULOSE AS ADJUNCTS TO A PRUDENT DIET IN THE TREATMENT OF MILD TO MODERATE HYPERCHOLESTEROLEMIA ARCHIVES OF INTERNAL MEDICINE LEVIN, E. G., MILLER, V. T., MUESING, R. A., STOY, D. B., BALM, T. K., LAROSA, J. C. 1990; 150 (9): 1822–27

Abstract

The effects of the administration of 5.1 g of psyllium or placebo (cellulose) twice daily for 16 weeks were compared as adjuncts to a prudent diet in the management of moderate hypercholesterolemia in a parallel, double-blind study. Psyllium decreased the total cholesterol level by 5.6% and the low-density lipoprotein cholesterol level by 8.6%, whereas the levels were unchanged in the placebo group. The high-density lipoprotein cholesterol level decreased during the diet stabilization period in both groups and returned to near-baseline values by week 16. Plasma triglyceride levels did not change substantially in either group. Subject compliance to treatment was greater than 95%. These data suggest that psyllium hydrophilic mucilloid in a twice-daily regimen may be a useful and safe adjunct to a prudent diet in the treatment of moderate hypercholesterolemia.

View details for DOI 10.1001/archinte.150.9.1822

View details for Web of Science ID A1990DY36400007

View details for PubMedID 2203322