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18F-FDOPA PET and MRI characteristics correlate with degree of malignancy and predict survival in treatment-naïve gliomas: a cross-sectional study. Journal of neuro-oncology Patel, C. B., Fazzari, E. n., Chakhoyan, A. n., Yao, J. n., Raymond, C. n., Nguyen, H. n., Manoukian, J. n., Nguyen, N. n., Pope, W. n., Cloughesy, T. F., Nghiemphu, P. L., Czernin, J. n., Lai, A. n., Ellingson, B. M. 2018

Abstract

To report the potential value of pre-operative 18F-FDOPA PET and anatomic MRI in diagnosis and prognosis of glioma patients.Forty-five patients with a pathological diagnosis of glioma with pre-operative 18F-FDOPA PET and anatomic MRI were retrospectively examined. The volume of contrast enhancement and T2 hyperintensity on MRI images along with the ratio of maximum 18F-FDOPA SUV in tumor to normal tissue (T/N SUVmax) were measured and used to predict tumor grade, molecular status, and overall survival (OS).A significant correlation was observed between WHO grade and: the volume of contrast enhancement (r?=?0.67), volume of T2 hyperintensity (r?=?0.42), and 18F-FDOPA uptake (r?=?0.60) (P?

View details for DOI 10.1007/s11060-018-2877-6

View details for PubMedID 29679199