Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis.

Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis. Cytokine Gubatan, J. n., Mitsuhashi, S. n., Longhi, M. S., Zenlea, T. n., Rosenberg, L. n., Robson, S. n., Moss, A. C. 2018; 103: 38–45

Abstract

Vitamin D has immune modulating effects on cytokines. Serum vitamin D levels are associated with the risk of relapse in patients with ulcerative colitis (UC), through unknown mechanisms. We tested the hypothesis that this beneficial role of vitamin D on UC is mediated through anti-inflammatory serum cytokine profiles.Serum samples from a prospective cohort of seventy UC patients in clinical remission were collected and baseline histological and endoscopic scores were recorded at enrollment. Clinical relapse events were recorded over the 12-month follow-up period. Serum vitamin D and cytokines levels (IL-6, IL-8, IL-17A, TNF-a, IFN-?, IL-4, IL-10) were quantified using ELISA. Linear regression was used to determine correlation between vitamin D and cytokine profiles. Logistic regression models were used to determine the association between serum cytokine profiles and baseline histologic mucosal healing and clinical relapse.Higher serum vitamin D levels positively correlated with higher ratios of IL-4?+?IL-10/IL-17A?+?TNF-a (r?=?0.37, P?

View details for DOI 10.1016/j.cyto.2017.12.023

View details for PubMedID 29324259

View details for PubMedCentralID PMC5808893