Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment. American journal of ophthalmology case reports Velez, G. n., Roybal, C. N., Binkley, E. n., Bassuk, A. G., Tsang, S. H., Mahajan, V. B. 2017; 5: 107–10

Abstract

To report a case of elevated intraocular pressure with retinal detachment.Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology.Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.

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