Skip to main content
 
Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
Stanford Health Care

Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenstrom macroglobulinemia and IgM monoclonal gammopathy.

Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenstrom macroglobulinemia and IgM monoclonal gammopathy. Journal of nephrology Tan, S. Y., Sibley, R. K., Belani, S., Iwasaki, S., Yankulin, L., Jonelis, T., Higgins, J. P., Kambham, N., Troxell, M. L. 2018

Abstract

IgM secreting myelomas or lymphomas, including Waldenstrom macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.

View details for PubMedID 30334170