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A critical role for telomeres in suppressing and facilitating carcinogenesis CURRENT OPINION IN GENETICS & DEVELOPMENT Artandi, S. E., DePinho, R. A. 2000; 10 (1): 39-46

Abstract

Progressive telomere shortening occurs with the division of primary human cells and activates tumor suppressor pathways, triggering senescence and inhibiting tumorigenesis. Loss of p53 function, however, allows continued cell division despite increasing telomere dysfunction and entry into telomere crisis. Recent data suggest that the severe chromosomal instability of telomere crisis promotes secondary genetic changes that facilitate carcinogenesis. Reactivation of telomerase stabilizes telomere ends and allows continued tumor growth.

View details for Web of Science ID 000085533800005

View details for PubMedID 10679392