New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Comprehensive Cardiac CT With Myocardial Perfusion Imaging Versus Functional Testing in Suspected CoronaryArtery Disease: The Multicenter, Randomized CRESCENT-II Trial.
Comprehensive Cardiac CT With Myocardial Perfusion Imaging Versus Functional Testing in Suspected CoronaryArtery Disease: The Multicenter, Randomized CRESCENT-II Trial. JACC. Cardiovascular imaging Lubbers, M., Coenen, A., Kofflard, M., Bruning, T., Kietselaer, B., Galema, T., Kock, M., Niezen, A., Das, M., van Gent, M., van den Bos, E., van Woerkens, L., Musters, P., Kooij, S., Nous, F., Budde, R., Hunink, M., Nieman, K. 2018; 11 (11): 1625–36Abstract
OBJECTIVES: This study sought to assess the effectiveness, efficiency, and safety of a tiered, comprehensive cardiac computed tomography (CT) protocol in comparison with functional testing.BACKGROUND: Although CT angiography accurately rules out coronary artery disease (CAD), incorporation of CT myocardial perfusion imaging as part of a tiered diagnostic approach could improve the clinical value and efficiency of cardiac CT in the diagnostic work-up of patients with angina pectoris.METHODS: Between July 2013 and November 2015, 268 patients (mean age 58 years; 49% female) with stable angina (mean pre-test probability 54%) were prospectively randomized between cardiac CT and standard guideline-directed functional testing (95% exercise electrocardiography). The tiered cardiac CT protocol included a calcium scan, followed by CT angiography if calcium was detected. Patients with=50% stenosis on CT angiography underwent CT myocardial perfusion imaging.RESULTS: By 6 months, the primary endpoint, the rate of invasive coronary angiograms without a European Society ofCardiology class I indication for revascularization, was lower in the CT group than in the functional testing group (2of130 [1.5%] vs. 10 of 138 [7.2%]; p= 0.035), whereas the proportion of invasive angiograms with a revascularization indication was higher (88% vs. 50%; p= 0.017). The median duration until the final diagnosis was 0 (0 of 0) days in the CTgroup and 0 (0 of 17) in the functional testing group (p< 0.001). Overall, 13% of patients randomized to CT required further testing, compared with 37% in the functional testing group (p< 0.001). The adverse event rate was similar (3%vs. 3%; p= 1.000), although the median cumulative radiation dose was higher for the CT group (3.1 mSv [interquartilerange: 1.6 to 7.8] vs. 0 mSv [interquartile range: 0.0 to 7.1]; p< 0.001).CONCLUSIONS: In patients with suspected stable CAD, a tiered cardiac CT protocol with dynamic perfusion imaging offers a fast and efficient alternative to functional testing. (Comprehensive Cardiac CT Versus Exercise Testing in SuspectedCoronary Artery Disease 2 [CRESCENT2]; NCT02291484).
View details for PubMedID 29248657