Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: a CIBMTR analysis. Journal of hematology & oncology Epperla, N., Ahn, K. W., Litovich, C., Ahmed, S., Battiwalla, M., Cohen, J. B., Dahi, P., Farhadfar, N., Farooq, U., Freytes, C. O., Ghosh, N., Haverkos, B., Herrera, A., Hertzberg, M., Hildebrandt, G., Inwards, D., Kharfan-Dabaja, M. A., Khimani, F., Lazarus, H., Lazaryan, A., Lekakis, L., Murthy, H., Nathan, S., Nishihori, T., Pawarode, A., Prestidge, T., Ramakrishnan, P., Rezvani, A. R., Romee, R., Shah, N. N., Sureda, A., Fenske, T. S., Hamadani, M. 2019; 12 (1): 6


BACKGROUND: There is a paucity of data on the role of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with angioimmunoblastic T-cell lymphoma (AITL). Using the CIBMTR registry, we report here the outcomes of AITL patients undergoing an allo-HCT.METHODS: We evaluated 249 adult AITL patients who received their first allo-HCT during 2000-2016.RESULTS: The median patient age was 56years (range=21-77). Majority of the patients were Caucasians (86%), with a male predominance (60%). Graft-versus-host disease (GVHD) prophylaxis was predominantly calcineurin inhibitor-based approaches while the most common graft source was peripheral blood (97%). Median follow-up of survivors was 49months (range=4-170months). The cumulative incidence of grade 2-4 and grade 3-4 acute GVHD at day 180 were 36% (95% CI=30-42) and 12 (95% CI=8-17), respectively. The cumulative incidence of chronic GVHD at 1year was 49% (95%CI 43-56). The 1-year non-relapse mortality (NRM) was 19% (95% CI=14-24), while the 4-year relapse/progression, progression-free survival (PFS), and overall survival (OS) were 21% (95% CI=16-27), 49% (95% CI=42-56), and 56% (95% CI=49-63), respectively. On multivariate analysis, chemoresistant status at the time of allo-HCT was associated with a significantly higher risk for therapy failure (inverse of PFS) (RR=1.73 95% CI=1.08-2.77), while KPS <90% was associated with a significantly higher risk of mortality (inverse of OS) (RR=3.46 95% CI=1.75-6.87).CONCLUSION: Our analysis shows that allo-HCT provides durable disease control even in AITL patients who failed a prior auto-HCT and in those subjects with refractory disease at the time of allografting.

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