Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects NANO LETTERS Cai, W. B., Shin, D. W., Chen, K., Gheysens, O., Cao, Q. Z., Wang, S. X., Gambhir, S. S., Chen, X. Y. 2006; 6 (4): 669-676

Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

View details for DOI 10.1021/nl052405t

View details for Web of Science ID 000236916200015

View details for PubMedID 16608262