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Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life. Epilepsy & behavior : E&B Roehl, K., Falco-Walter, J., Ouyang, B., Balabanov, A. 2019

Abstract

OBJECTIVE: This study evaluates the efficacy of a modified ketogenic diet (MKD) on seizure frequency, severity, and quality of life (QOL), as well as potential complications of MKD therapy among adults with drug-resistant epilepsy (DRE).METHODS: Changes in seizure frequency, severity, QOL, and side effects were retrospectively examined among adults, =17?years of age, with DRE (=2 antiepileptic drugs [AEDs]), after 3?months of MKD therapy. Attention was paid to medication or vagus nerve stimulator (VNS) changes as well to evaluate potential confounders.RESULTS: A total of 60% (n?=?33) of the 55 individuals reported =50% seizure frequency improvement, 42 (76%) reported improvement in seizure severity, and 48 (87%) reported improvement in QOL. More patients following a modified ketogenic diet - 15?g net carbohydrate daily (MKD-15) (95%) compared with a MKD-50 (69%) reported improvement in QOL (p?=?0.02). Weight among the entire sample declined from 77.5 (20) kg to 73.9 (19.0) kg (p?

View details for PubMedID 30867113