Ku80 Deletion Suppresses Spontaneous Tumors and Induces a p53-Mediated DNA Damage Response CANCER RESEARCH Holcomb, V. B., Rodier, F., Choi, Y., Busuttil, R. A., Vogel, H., Vijg, J., Campisi, J., Hasty, P. 2008; 68 (22): 9497–9502

Abstract

Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80(-/-) mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis, Ku80 deletion ameliorated tumor burden in APC(MIN) mice and increased a p53-mediated DNA damage response, DNA lesions, and chromosomal rearrangements. Thus, contrary to its assumed role as a caretaker tumor suppressor, Ku80 facilitates tumor growth most likely by dampening baseline cellular DNA damage responses.

View details for DOI 10.1158/0008-5472.CAN-08-2085

View details for Web of Science ID 000261136600048

View details for PubMedID 19010925

View details for PubMedCentralID PMC4034752