It is well accepted that obstructive sleep apnea (OSA) is a risk factor for hypertension. In the subgroup of patients with resistant hypertension (rHTN), OSA appears to be particularly rampant; suggesting sleep disordered breathing may contribute to pathological mechanisms that make blood pressure difficult to control. This article explores potential mechanisms by which sleep apnea contributes to rHTN, and examines the impact of treating OSA with positive airway pressure therapy on blood pressure control. In recent years, there has been a surge of interest in randomized controlled trials of positive airway pressure therapy in patients with OSA and rHTN, because patients with rHTN respond poorly to medications. As a result, identifying novel targets for blood pressure control in this high-risk population has become paramount.
View details for PubMedID 26671301