The fibroblast-populated collagen matrix as a model of wound healing: a review of the evidence WOUND REPAIR AND REGENERATION Carlson, M. A., Longaker, M. T. 2004; 12 (2): 134–47


The fibroblast-populated collagen matrix (FPCM) has been utilized as an in vitro model of wound healing for more than 2 decades. It offers a reasonable approximation of the healing wound during the phases of established granulation tissue and early scar. The gross and microscopic morphology of the FPCM and the healing wound are similar at analogous phases. The processes of proliferation, survival/apoptosis, protein synthesis, and contraction act in similar directions in these two models, and the response to exogenous agents also is consistent between them. If its limitations are respected, then the FPCM can be used as a model of the healing wound.

View details for DOI 10.1111/j.1067-1927.2004.012208.x

View details for Web of Science ID 000220852800003

View details for PubMedID 15086764