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Molecular targets and the treatment of myeloid leukemia MOLECULAR GENETICS AND METABOLISM Ikeda, A., Shankar, D. B., Watanabe, M., Tamanoi, F., Moore, T. B., Sakamoto, K. M. 2006; 88 (3): 216-224

Abstract

Leukemia is a multistep process involving accumulation of genetic alterations over time. These genetic mutations destroy the delicate balance between cell proliferation, differentiation, and apoptosis. Traditional approaches to treatment of leukemia involve chemotherapy, radiation, and bone marrow transplantation. In recent years, specific targeted therapies have been developed for the treatment of leukemia. The success of treatment of acute promyelocytic leukemia with All Trans Retinoic Acid (ATRA) and CML with imatinib have lead to increased efforts to identify targets that can be inhibited by small molecules for treatment of hematological malignancies. In this review, we describe the current advances in the development of targeted therapy in acute myeloid leukemia.

View details for DOI 10.1016/j.ymgme.2006.03.011

View details for Web of Science ID 000239615900003

View details for PubMedID 16678459