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Pharmacokinetics of Tecarfarin and Warfarin in Patients with Severe Chronic Kidney Disease THROMBOSIS AND HAEMOSTASIS Albrecht, D., Turakhia, M. P., Ries, D., Marbury, T., Smith, W., Dillon, D., Milner, P. G., Midei, M. G. 2017; 117 (11): 2026–33
Abstract
Chronic kidney disease (CKD) complicates warfarin anticoagulation partially through its effect on CYP2C9 activity. Tecarfarin, a novel vitamin K antagonist, is not metabolized by CYP2C9. To evaluate the effect of CKD on their metabolism, we measured PK parameters of warfarin and tecarfarin in subjects with and without CKD. CKD subjects with estimated glomerular filtration rate?
View details for PubMedID 28933798