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Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult CLINICAL INFECTIOUS DISEASES Chiu, C. Y., Rouskin, S., Koshy, A., Urisman, A., Fischer, K., Yagi, S., Schnurr, D., Eckburg, P. B., Tompkins, L. S., Blackburn, B. G., Merker, J. D., Patterson, B. K., Ganem, D., DeRisi, J. L. 2006; 43 (8): E71-E76

Abstract

A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.

View details for Web of Science ID 000240666200029

View details for PubMedID 16983602