Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging CURRENT OPINION IN BIOTECHNOLOGY Swijnenburg, R., van der Bogt, K. E., Sheikh, A. Y., Cao, F., Wu, J. C. 2007; 18 (1): 38-45


Over the past few years, human embryonic stem cells (hESCs) have gained popularity as a potentially ideal cell candidate for tissue regeneration. In particular, hESCs are capable of cardiac lineage-specific differentiation and confer improvement of cardiac function following transplantation into animal models. Although such data are encouraging, there remain significant hurdles before safe and successful translation of hESC-based treatment into clinical therapy, including the ability to assess cells following transplant. To this end, molecular imaging has proven a reliable methodology for tracking the long-term fate of transplanted cells. Imaging reporter genes that are introduced into the cells before transplantation enable non-invasive and longitudinal studies of cell viability, location and behaviour in vivo. Therefore, molecular imaging is expected to play an increasing role in characterizing the biology and physiology of hESC-derived cardiac cells in living subjects.

View details for DOI 10.1016/j.copbio.2006.12.003

View details for Web of Science ID 000244593000007

View details for PubMedID 17196814