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Serum total testosterone levels in a patient with late onset 21-hydroxylase deficiency and a twin gestation FERTILITY AND STERILITY Mains, L. M., Lathi, R. B., Burney, R. O., Dahan, M. H. 2007; 87 (5)

Abstract

To present serum androgen levels during pregnancy in a twin gestation complicated by maternal late onset 21-hydroxylase deficiency.Case report.University teaching hospital reproductive endocrinology and infertility practice.A 27-year-old with nonclassic 21-hydroxylase deficiency and infertility, twin female fetuses, and elevated androgens.Steroid replacement.Serum T and 17-hydroxyprogesterone (17-OHP) levels.Elevated androgen levels persisted throughout pregnancy in spite of aggressive steroid replacement. However, twin girls were born without any evidence of virilization.The changes associated with a twin gestation may result in excessive stimulation of androgens in mothers with nonclassic 21-hydroxylase deficiency. However, the increased placental aromatase provides protection.

View details for DOI 10.1016/j.fertnstert.2006.07.1545

View details for Web of Science ID 000207688100002

View details for PubMedID 17418835